All about that Amide Bond: The Sixth Chemical Protein Synthesis (CPS) Meeting.
نویسندگان
چکیده
Endless potential: The sixth Chemical Protein Synthesis Meeting, held recently in St. Augustine, Florida, showed the potential of peptide and protein chemistry when applied toward understanding and controlling complex biological processes. This report highlights the diverse and cutting-edge protein chemistry presented at the meeting.
منابع مشابه
Asparagine amide metabolism in developing cotyledons of soybean.
Magic-angle single and double cross-polarization (13)C and (15)N NMR spectra have been obtained of lyophilized soybean cotyledons cultured on media containing, as the only nitrogen source, [4-(13)C, amide-(15)N]asparagine. Single cross-polarization NMR shows directly and unambiguously that both labels from asparagine are incorporated extensively and nonrandomly into protein by the developing co...
متن کاملAn efficient computational model to predict protonation at the amide nitrogen and reactivity along the C-N rotational pathway.
N-Protonation of amides is critical in numerous biological processes, including amide bonds proteolysis and protein folding as well as in organic synthesis as a method to activate amide bonds towards unconventional reactivity. A computational model enabling prediction of protonation at the amide bond nitrogen atom along the C-N rotational pathway is reported. Notably, this study provides a blue...
متن کاملProtein assembly by orthogonal chemical ligation methods.
Chemical synthesis harbors the potential to provide ready access to natural proteins as well as to create nonnatural ones. The Staudinger ligation of a peptide containing a C-terminal phosphinothioester with a peptide containing an N-terminal azide gives an amide with no residual atoms. This method for amide bond formation is orthogonal and complementary to other ligation methods. Herein, we de...
متن کاملProtein Assembly Using the Staudinger Ligation
Introduction New methods are facilitating the total chemical synthesis of proteins. In particular, the chemical ligation of synthetic peptides provides a convergent route to proteins. Currently, the most common ligation method is “native chemical ligation” [1]. In native chemical ligation, the thiolate of an N-terminal cysteine residue of one peptide attacks the C-terminal thioester of a second...
متن کاملSynthesis and Characterization of Polyamide-66/Calcium Carbonate Composites
Polyamide-66(PA66)/CaCO3 micro- and nano-composites were prepared using a polymer solution method at filler loading of 0, 1, 2 and 3 weight percent. Nano-size of CaCO3 was synthesized by micro-emulsion technique. The material was characterized by XRD, SEM, FTIR and UV-VIS techniques. XRD results of composites suggested that CaCO3 particles are found in the amorphous phase of the semi-crystallin...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Chembiochem : a European journal of chemical biology
دوره 16 17 شماره
صفحات -
تاریخ انتشار 2015